NT-proBNP在终末期肾病中的应用

心血管疾病是在透析过程中导致终末期肾病患者死亡的主要原因⁽¹⁾。为了了解除传统的透析患者的心血管危险因素外，透析患者高死亡率的潜在机制，研究人员调查了腹膜透析（PD）患者的肠道通透性、循环细菌碎片和容量超载之间的关系⁽²⁾。

Gut permeability, circulating bacterial fragments and measures of congestion in peritoneal dialysis.（Clin Kidney J. 2024 Mar 6;17(3):sfae056. doi: 10.1093/ckj/sfae056. ）

在这项前瞻性观察研究中，连续招募了108名成年PD患者，并评估了循环细菌片段、N末端B型钠尿肽前体（NT-proBNP）、钙保护素和唑啉蛋白水平⁽²⁾。

 

液体超负荷标志物

NT-proBNP被认为是左心室紧张和血管内液体超负荷的标志物^（3,4）。通过使用Biomedica的ELISA试剂盒和多频生物电阻抗生物电阻抗谱检测血清中NT-proBNP的水平来定量反映液体超负荷的情况⁽²⁾。

 

NT-proBNP ELISA assay kit (cat. no. SK-1204)

√CE标记-用于欧盟的IVD
√操作简单-2步法，可以在每个实验室中运行
√包含高和低试剂盒对照
√可靠-根据国际质量指南进行验证
√可信-在125篇出版物中被广泛引用

参考文献

1.   Cardiovascular complications in chronic kidney disease: a review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association. Zoccali C, Mallamaci F, Adamczak M, de Oliveira RB, Massy ZA, Sarafidis P, Agarwal R, Mark PB, Kotanko P, Ferro CJ, Wanner C, Burnier M, Vanholder R, Wiecek A. Cardiovasc Res. 2023 Sep 5;119(11):2017-2032. doi: 10.1093/cvr/cvad083. PMID: 37249051; PMCID: PMC10478756.

2.   Gut permeability, circulating bacterial fragments and measures of congestion in peritoneal dialysis. Li C, Ng JK, Chan GC, Fung WW, Lai KB, Poon PY, Luk CC, Chow KM, Szeto CC. Clin Kidney J. 2024 Mar 6;17(3):sfae056. doi: 10.1093/ckj/sfae056. PMID: 38516523; PMCID: PMC10956420. 

3.   NT-proBNP, fluid volume overload and dialysis modality are independent predictors of mortality in ESRD patients. Paniagua R, Ventura MD, Avila-Díaz M, Hinojosa-Heredia H, Méndez-Durán A, Cueto-Manzano A, Cisneros A, Ramos A, Madonia-Juseino C, Belio-Caro F, García-Contreras F, Trinidad-Ramos P, Vázquez R, Ilabaca B, Alcántara G, Amato D. Nephrol Dial Transplant. 2010 Feb;25(2):551-7. doi: 10.1093/ndt/gfp395. Epub 2009 Aug 12. PMID: 19679559.

4.   Determination of volume overload by bioelectrical impedance analysis and NT-proBNP in diabetic pre-dialysis patients. Acta Endocrinol (Buchar). Yildirim Y, Kara AV, Kilinç F, Aydin F, Aydin E, Yilmaz Z, Kadiroglu AK, Yilmaz ME. 2016 Jan-Mar;12(1):19-25. doi: 10.4183/aeb.2016.19. PMID: 31258795; PMCID: PMC6586753.